ACT Chief Minister and Minister for Health Ms Katy Gallagher launched the ACT program on 16 December 2011 at the ACT Legislative Assembly. Speakers included:

• Ms Nicole Wiggins, Canberra Alliance for Harm Minimisation and Advocacy
• Associate Professor Paul Dietze, Burnet Institute

Download the launch flyer

Naloxone is a schedule 4 drug in the ACT that is routinely used by health personnel to reverse opioid overdoses. Consistent with developments internationally, the ACT alcohol, tobacco and other drug sector has designed a public health program to expand naloxone availability in the ACT with the aim of reducing opioid overdose morbidity and mortality.

The Expanding Naloxone Availability in the ACT (ENAACT) program involves comprehensive overdose management training and the supply on prescription of take-home naloxone to eligible participants who are not health professionals.

People prescribed take-home naloxone will be administered it by a trained peer (usually a friend or family member) in the event of an opioid (primarily heroin) overdose.

The training will be conducted over a two-year year period with 200 participants. The training for opioid users and other potential overdose witnesses will be conducted in groups of 10 people trained in each group. Eligible participants who successfully complete the training will be prescribed naloxone by a General Practitioner upon reaching a level of competence and assessment.

Participants will participate in a training program, provided by Canberra Alliance for Harm Minimisation and Advocacy (CAHMA) staff and volunteers who are ‘Approved Trainers’. The training program has been adapted from international models and will involve:

• Recruitment to participate in program
• Consent to participate in the program evaluation
• Pre-training knowledge assessment questionnaire
• Education/training session provided by CAHMA
• Completion of post-training knowledge assessment questionnaire
• Consultation with General Practitioner prescriber with pre- and post-questionnaire results
• Consultation bulk-billed with Medicare Card
• Prescription for naloxone issued by General Practitioner on site to eligible participants
• Provision of naloxone on prescription to eligible participants

Topics addressed in the training program will include recognising opioid ovedose; risk factors for opioid overdose and responding to opioid overdose (including resuscitation techniques, calling for an ambulance and administration of naloxone).

An independent evaluation of the program will assess the implementation of the program and participants’ experiences of the program. It will contribute significantly to new knowledge about the implementation of expanded naloxone availability in the ACT context.

The program will be overseen by the ENAACT Committee which includes general practitioners, drug treatment workers, consumers and family members, and researchers.

The program will commence in the ACT in early 2012.

An independent evaluation of the program will assess the implementation of the program and participants’ experiences of the program. It will contribute significantly to new knowledge about the implementation of expanded naloxone availability in the ACT context.The Chief Investigators are Associate Professor Paul Dietze, Burnet Institute and Professor Simon Lenton, National Drug Research Institute.Further information about the evaluation will be available in early 2012.

The purpose of the Committee is to provide expert guidance and support to and develop a program to expand naloxone availability in the ACT.  For further information about the Committee, including 2011 terms of reference and membership, please download the Committee’s 2011 terms of reference.

For further information contact Carrie Fowlie, ENAACT Chair, on carrie@atoda.org.au or (02) 6255 4070.

This Question and Answer document was developed by Professor Simon Lenton, National Drug Research Institute, Curtin University (s.lenton@curtin.edu.au), as a member of, and for use by, the ENAACT Committee.  It is hoped that this document will raise awareness and support stakeholder engagement in this important program.

Download the Expanding Naloxone Availability in the ACT Q&A (December 2011)

Naloxone: long history as safe, reliable and effective medication

For over 40 years naloxone has been used in medicine to reverse the effects of heroin and other opioids. In this capacity it has been shown to be safe, reliable and effective. Naloxone is an opioid antagonist. It does not produce any intoxication and has no effect on people who don’t have opioids in their body.  In Australia, as elsewhere, naloxone is widely used in hospital emergency departments and most ambulance services as a key response to opioid overdose.

In 1992 Professor John Strang from Kings College London argued for the wider distribution of naloxone to those who come into contact with people who inject drugs in order to help prevent overdose mortality and morbidity. This argument was subsequently endorsed by Australian researchers and academics from the mid-1990s. In 2009, the case for the wider distribution of naloxone was reiterated on the basis of findings emerging from (primarily ‘peer’) naloxone distribution programs running overseas.

The argument for the wider distribution of naloxone stems from findings that show that:

• People who inject drugs commonly experience overdose;
• Overdoses are often witnessed by people who can respond;
• Peers, family members and others can successfully respond to assist in the management of overdoses among people who inject drugs; and,
• Peers and family members are keen to respond to overdoses if they occur.

Adapted from a resource produced by Associate Professor Paul Dietze, Burnet Institute and Professor Simon Lenton, National Drug Research Institute (December 2010). Read The Case for the Wider Distribution of Naloxone in Australia.

ACT Naloxone Program Launch Media Briefing (December 2011)

This Media Briefing includes comments from professionals related to expanding naloxone availability in the ACT and Australia, including:

• Professor Simon Lenton, National Drug Research Institute
• Dr Ingrid Van Beek AM, Founding Medical Director, Sydney Medically Supervised Injecting Centre
• Mr Michael Moore, Chief Executive Officer, Public Health Association of Australia
• Mr Tony Trimingham OAM, Founder and CEO of Family Drug Support
• Carrie Fowlie, Executive Officer, ATODA

Download the Media Briefing.

Recent media reports:

Overdose antidote trial begins in Canberra
19 December 2011: ABC News
http://www.abc.net.au/news/2011-12-16/overdose-antidote-trial-begins/3736138?section=act

Overdose antidote training
17 December 2011: AM with Tony Eastley, ABC News
http://www.abc.net.au/am/content/2011/s3393149.htm

Capital addicts get help at home
17 December 2011: The Canberra Times
http://www.canberratimes.com.au/news/local/news/general/capital-addicts-get-help-at-home/2396351.aspx?storypage=0

Cover Page: Overdose Packs for Capital’s Addicts
17 December 2011: The Canberra Times
http://www.atoda.org.au/wp-content/uploads/Overdose-Packs-for-Capitals-Addicts.pdf

Australian first Overdose Management Program launched at Alcohol, Tobacco and Other Drug Awards
16 December 2011: Katy Gallagher MLA, Media Release
http://www.chiefminister.act.gov.au/media.php?v=11241&m=52

Radio Interview with Dr Ingrid van Beek about Australia’s first overdose program to provide naloxone
15 December 2011: 2CC Drive Show with Mike Welsh

Overdose Antidote to be Trialed in Canberra
24 June 2011: ABC News
“Drug policy researchers say they are hoping to begin a new training initiative in Canberra to reverse drug overdoses.” View the full Overdose Antidote To Be Trialed in Canberra article.

Interview with Associate Professor Paul Dietze on Naloxone
24 June 2011: Radio National, ABC News

http://www.abc.net.au/news/2011-06-24/overdose-antidote-to-be-trialed-in-canberra/2769976

Bid to Curb ACT Drug Overdoses
19 June 2011: The Canberra Times
“It is in the interests of the ACT Government and the community to implement strategies to reduce opioid overdoses now so preventative interventions can be evaluated and refined before the number of overdoses increases further.” The association [ATODA] has renewed the 15-year campaign for access to the lifesaving drug naloxone. Download the Bid to Curb ACT Drug Overdoses Article.

Overdose Antidote Scheme ‘Could Save Lives’
1 December 2010: ABC News
The ACT Government has expressed interest in a scheme to help friends and relatives of drug users to resuscitate them from overdoses.
 The Alcohol Tobacco and Other Drug Association (ATODA) has proposed an ACT trial where associates of heroin and opiate users would be permitted to administer the anti-overdose drug Narcan….
”[Narcan] is already widely used in Australia and internationally by paramedics and emergency room staff in suspected cases of opioid overdoes and it’s usually administered intramuscularly so a shot to the leg or in the bottom,” said ATODA executive officer Carrie Fowlie.
” 
Visit http://www.abc.net.au/news/stories/2010/12/01/3081221.htm to view the full article.

666 ABC Radio Naloxone Program Interviews
1 December 2010: 666 ABC Radio
Two interviews were conducted by Ross Solly on 666 ABC Radio related to Naloxone with Health Minister Ms Katy Gallagher, MLA and Ms Carrie Fowlie, Executive Officer, ATODA.
Download the interview with Health Minister Ms Katy Gallagher, MLA.
Download the interview with Ms Carrie Fowlie, Executive Officer, ATODA.

Overdose Antidote Scheme Proposed
1 December 2010
: The Canberra Times
ACT Health is investigating a trial program that would allow the families and friends of heroin and opiate users to resuscitate them in the event of an overdose….
The proposal, which would be an Australian first, was put to ACT Health by the Alcohol Tobacco and Other Drug Association….
If the association’s proposal succeeds, an opiate user would be prescribed Narcan to be administered by a third party such as a housemate, partner or family member. That third party would be trained to administer the drug in the event of overdose….
ACT Health spokeswoman Hasnah Scheding said the organisation was investigating whether there were legal barriers to introducing a pilot program and whether it had the support of local medical practitioners.
“Preliminary advice is that it is something that could potentially save lives and, if targeted well and supported by key groups locally, it may be a valuable addition to current drug overdose prevention interventions in the ACT,” she said. Download the Overdose Antidote Scheme Proposed Article.

Call for Public Access to Overdose Treatment

25 October 2010: ABC News
“Groups dealing with narcotics users and their families are pushing for greater public access to a drug that can reverse overdoses.” View the Call for Pulic Access to Overdose Treatment article.

The needle and the damage done
24 October 2010: The Canberra Times
“Academic reviews suggested making naloxone available in the heroin-using community could help reduce the number of killer overdoses.” Download The needle and the damage done article.

Intranasal Naloxone
13 October 2008: ABC Radio National
http://www.abc.net.au/radionational/programs/healthreport/intranasal-naloxone/3190286

In November 2011, Carrie Fowlie, Executive Officer, ATODA, visited three services in New York City that provide naloxone on prescription as part of their overdose management programs.  The programs were:

• Harm Reduction Coalition (Manhattan, NYC)
• The Corner Project (Washington Heights, NYC)
• St Ann’s Corner for Harm Reduction (The Bronx, NYC)

ATODA would like to express its gratitude to these programs and their staff for sharing their expertise and experiences to support the development of a program in the ACT to expand naloxone availability.

Dr. Sharon Stancliff, Medical Director, Harm Reduction Coalition & Carrie Fowlie, ATODA

The Harm Reduction Coalition is a national advocacy and capacity-building organisation that promotes the health and dignity of individuals and communities impacted by drug use. HRC advances policies and programs that help people address the adverse effects of drug use including overdose, HIV, hepatitis C, addiction, and incarceration. www.harmreduction.org

Dr Sharon Stancliff, Medical Director, Harm Reduction Coalition (East), has been a leader in promoting and providing naloxone as part of overdose prevention programs.  Dr Stancliff visited the ACT in December 2010 as part of the Australasian Professional Society on Alcohol and Drugs Conference.  For further information see:

Paper 280 – Symposium – Policy and Practice – Increasing Community Access to Naloxone to Prevent Opioid Overdose Deaths: Lessons for Australia. Drug and Alcohol Review. V29. December 2010 http://onlinelibrary.wiley.com/doi/10.1111/j.1465-3362.2010.00261.x/pdf

Get The SKOOP Kit, Harm Reduction Coalition (Manhattan, NYC)

Skills and Knowledge on Overdose Prevention Project (SKOOP) trains heroin users and their associates to utilise naloxone kits and to provide introductions to overdose prevention, training of trainers and technical assistance for staff of local services. For more information about when the project began (2006) see this powerpoint: www.harmreduction.org/downloads/OverviewOfOverdose.ppt

Some of the dedicated staff from The Corner Project (Washington Heights, NYC)

The Corner Project’s mission is to significantly decrease behaviors among drug users that put them at the highest risk for HIV and hepatitis transmission. They provide  participants with safer-injection and safer-sex supplies, harm reduction education and literature, as well as case management and referrals, supportive counseling, wellness evaluations, crisis intervention, and other crucial health and social services. www.cornerproject.org

Example of harm reduction kits from The Corner Project (Washington Heights, NYC)

Find out more about what they do through their youtube video: http://www.youtube.com/watch?v=CbphStspogw (2009)

Some of the dedicated staff from St Ann’s Corner of Harm Reduction (The Bronx, NYC)

St. Ann’s Corner of Harm Reduction (SACHR) has been meeting drug users where they are: on the streets and actively engaged in high-risk lifestyles or within the center, where they seek an individualized and comprehensive cluster of healing services. www.sachr.org

Demonstration of GP assessing and prescribing naloxone to a patient (The Bronx, NYC)

This is an example of the assertive outreach services provided by the Harm Reduction Coalition in partnership with the St Ann’s Corner of Harm Reduction.  Other concurrent street-based outreach services being provided included safe sex kits and information; needle and syringe packs and information; peer support; and referrals.

Carrie Fowlie, ATODA & Bill Matthews, Harm Reduction Coalition (The Bronx, NYC)

ATODA’s submission to the 2011/2012 ACT Budget included a proposal for a program with the aim of reducing and preventing opioid overdoses in the ACT, which includes Naloxone. Download the ATODA Budget Submission.

2/52 Update
Volume 9, 21 December 2011
Fortnightly update of the ACT Medicare Local
Australia’s First Naloxone Overdose Management Program in the ACT

Medical Observer
12 December 2011
Community naloxone gets green light in ACT

Medical Observer
6 December 2011
Wider naloxone access to cut heroin deaths

Medical Observer
15 November 2011
Hero heroin – a solution to overdoses?

Drug Info (September 2011)
(Vol 9, No3) Newsletter of the Australian Drug Foundation’s DrugInfo service
Professor Simon Lenton, National Drug Research Institute
Moves toward wider availability of Naloxone. Despite the “heroin shortage”, about one Australian a day still dies from an overdose, most involving heroin.  For about 20 years there have been calls to make naloxone more available to people who use opioids, their friends, family members and other potential overdose witnesses to help prevent overdose deaths.

I’m the Evidence. Naloxone Works
Harm Reduction Coalition
I’m the Evidence uses video advocacy to give a face and a voice to overdose stories happening all over the world. It provides an outlet for these stories as a way to mobilize the drug using community and harm reduction advocates around the promotion of naloxone availability and use.  For more information visit: www.facebook.com/NaloxoneWorks

Time Magazine (19 September 2011)
Szalavitz, M. (2011) Fueled by Growing Painkiller Use, Overdose Deaths and Child Poisonings Are on the Rise. Time, 19 September 2011.

Of Substance Magazine (July 2011)
(Vol 9. No 2)
Of Substance is a free, triannual magazine of the Australian National Council on Drugs that addresses alcohol, tobacco and other drug (ATOD) issues and problems in Australia today (www.ofsubstance.org.au).Dietze, P. 2011. When a friend drops:The push to distribute potential-lifesaving naloxone. Of Substance. Vol 9. No 2.

ACTCOSS Update Newsletter (June 2011)
(Issue 56 – Winter 2011)
Update is the quarterly newsletter of the ACT Council of Social Service, the peak body representative body for people living with low incomes or disadvantage and for not-for-profit community organizations in the ACT (www.actcoss.org.au)
Overdose prevention and intervention:  ACT leads the way

AAC Newsletter (May – June 2011)
The Newsletter of the AIDS Action Council of the ACT. The AIDS Action Council of the ACT provides services to the ACT community, aimed at eliminating further transmission of HIV and minimising the personal and social impacts of HIV and AIDS. (http://aidsaction.org.au/aac/).
Naloxone program (May – June 2011) Article and Opinion Piece p.6

GP ACTion Newsletter (February & May 2011)
GP ACTion is the quarterly newsletter of the ACT Division of General Practice, whose core focus to support general practice in delivering local health solutions (www.actdgp.asn.au).
Update on Expanding Naloxone Availability in the ACT (Vol 144 May 2011)
Overdose Prevention and Intervention: Naloxone Trial (Vol 143 February 2011)

Pharmacy Guild of Australia – ACT Branch Bulletin (April 2011)
Pharmacy Guild of Australia is an advocate for community pharmacy and a vital contributor to improving health outcomes for all Australians.
Article available soon.

Families and Friends for Drug Law Reform (FFDLR) Newsletter (March 2011)
FFDLR believes that prohibition laws are more the problem than the solution; it seeks laws and policies which will eliminate the deaths and minimise the health and social harm and, amongst many things, produces a monthly newsletter (www.ffdlr.org.au). Peer Administered Naloxone Program in the ACT (March 2011) Article

Anex Bulletin (October 2010)
The Anex Bulletin is the Australian Needle and Syringe Program (NSP) sector’s quarterly magazine and highlights new information, research findings and emerging issues for harm reduction workers. This issue of the magazine provides information on Naloxone and its role in reviving people who are suffering from an opioid overdose (www.anex.org.au).
Anex.
Griffiths, P. 2010. Naloxone 101: Anex Bulletin Volume 9 Issue 1, October 2010. Melbourne.

Below are some recent conference and symposium presentations related to expanding naloxone availability.

Centre for Research Excellence in Injecting Drug Use Colloquium (18 July)
ENAACT Committee members Associate Professor Paul Dietze, Professor Simon Lenton and Carrie Fowlie presented at the inaugural Centre for Research Excellence in Injecting Drug Use colloquium in Melbourne.
Strategic advocacy and the ʻtime lagʼ: Expanding naloxone availability in the ACT
by Carrie Fowlie

Making Naloxone Available to Potential Overdose Witnesses: evidence and policy opportunities
Simon Lenton, PhD MPsych(clin), National Drug Research Institute
The second annual Drug Policy Modelling Program (DPMP) Symposium was held on Friday, 18 March 2011 in Sydney. Professor Simon Lenton presented on naloxone and highlighted some of the work taking place in the ACT.  For further information regarding the symposium visit www.dpmp.unsw.edu.au. Download Professor Lenton’s presentation.

International Naloxone Symposium
‘Building on the Capital’ – 30^th International Australasian Professional Society on Alcohol and other Drugs (APSAD) Conference
National Convention Centre, 28 November – 1 December 2010
A peer-administered naloxone symposium was held at the Conference, which looked at increasing community access to naloxone to prevent opioid overdose deaths: lessons for Australia.  Presenters included experts, Paul Dietze, Simon Lenton, Nicholas Lintzeris, Sharon Stancliff, Howard Wren (ACT Ambulance Service), and Nicole Wiggins (CAHMA).  Download the program for further information.

Distributing Naloxone … because dead addicts NEVER recover
Dr Sarz Maxwell, Chicago Recovery Alliance
Presentation at the Australian Drug Conference in Melbourne 25 – 26 October 2010. Download Dr Sarz Maxwell’s presentation.

For research and evidence summaries about other issues visit: http://www.atoda.org.au/publications/research-summaries/.  You can also subscribe to the ACT ATOD Research eBulletin, by emailing ebulletin@atoda.org.au

Below are some recent naloxone references, compiled by Professor Simon Lenton, National Drug Research Institute and social scientist David McDonald – most are available from the National Drugs Sector Information Service (NDSIS) at the Alcohol and Other Drug Council of Australia http://ndsis.adca.org.au.

Anex (2010), Lifesavers: a position paper on access to Naloxone Hydrochloride for potential opioid overdose witnesses. Anex, Melbourne, Australia. http://www.anex.org.au/downloads/AnexPositionPaperNaloxoneOctober2010.pdf.

Australian National Council on Drugs (2001). Naloxone availability: A Secondary Position Paper on Heroin Related Overdoses. ANCD Position Paper. Canberra. http://www.ancd.org.au/images/PDF/Positionpapers/pp_heroin_overdoses3.pdf.

Enteen, L., Bauer, J., McLean, R., Wheeler, E., Huriaux, E., Kral, A., et al. (2010). Overdose Prevention and Naloxone Prescription for Opioid Users in San Francisco. Journal of Urban Health, 1-11.

Opiate overdose is a significant cause of mortality among injection drug users (IDUs) in the United States (US). Opiate overdose can be reversed by administering naloxone, an opiate antagonist. Among IDUs, prevalence of witnessing overdose events is high, and the provision of take-home naloxone to IDUs can be an important intervention to reduce the number of overdose fatalities. The Drug Overdose Prevention and Education (DOPE) Project was the first naloxone prescription program (NPP) established in partnership with a county health department (San Francisco Department of Public Health), and is one of the longest running NPPs in the USA. From September 2003 to December 2009, 1,942 individuals were trained and prescribed naloxone through the DOPE Project, of whom 24% returned to receive a naloxone refill, and 11% reported using naloxone during an overdose event. Of 399 overdose events where naloxone was used, participants reported that 89% were reversed. In addition, 83% of participants who reported overdose reversal attributed the reversal to their administration of naloxone, and fewer than 1% reported serious adverse effects. Findings from the DOPE Project add to a growing body of research that suggests that IDUs at high risk of witnessing overdose events are willing to be trained on overdose response strategies and use take-home naloxone during overdose events to prevent deaths.

Kinner, SA, Preen, DB, Kariminia, A, Butler, T, Andrews, JY, Stoové, M & Law, M (2011), ‘Counting the cost: estimating the number of deaths among recently released prisoners in Australia’, Medical Journal of Australia, vol. 195, no. 2, pp. 64-8, Free full text http://www.mja.com.au/public/issues/195_02_180711/kin10879_fm.html.

How many ex-prisoners die soon after release from prison, and what do they die from?

Research reported in the Medical Journal of Australia reveals that ‘The estimated annual number of deaths among recently released prisoners in Australia is considerably greater than the annual number of deaths in custody, highlighting the extreme vulnerability of this population on return to the community’. The researchers estimate that ‘between 380 and 527 people released from prison in 2007–08 died within 1 year of release, with a disproportionate number dying in the first 4 weeks’.

They found that ‘a large proportion of deaths in both cohorts [NSW and WA] was drug-related, highlighting the ongoing need to develop and implement evidence-based strategies to reduce drug-related death among ex-prisoners. One such strategy is opiate substitution therapy, which has been associated with reduced mortality, reincarceration and hepatitis C infection in ex-prisoners. Yet, despite unambiguous endorsement of opiate substitution therapy in the National Corrections Drug Strategy 2006–2009, its provision in Australian prisons remains inconsistent. Another suggested approach is the provision of naloxone for peer administration. A clinical trial of naloxone provision to those at risk of overdose on release from prison has been proposed but not yet conducted’.

However, ‘Although drug overdose is a leading cause of death for recently released prisoners, more than 50% of deaths in this study were not drug-related, and at least two-thirds of deaths in the first year occurred more than 1 month after release. These findings underscore the importance of moving beyond simplistic messages about reduced drug tolerance and overdose risk in the first few weeks of release’.

Mayet, S, Manning, V, Williams, A, Loaring, J & Strang, J (2011). Impact of training for healthcare professionals on how to manage an opioid overdose with naloxone: effective, but dissemination is challenging. International Journal of Drug Policy, vol. 22, no. 1, pp. 9-15. http://findings.org.uk/count/downloads/download.php?file=Mayet_S_5.txt

Naloxone-based overdose prevention training spread slowly in England
After being initiated in London, training for addiction treatment staff in managing opiate overdose using naloxone cascaded to other staff and to patients at a disappointingly slow pace; on average each clinician trainee trained one drug user every 11 months. Is this a sign of the low priority given to overdose prevention?

McAuley, A. (2011). The impact of drug-related death on staff who have experienced it as part of their caseload: An exploratory study. Journal of Substance Use, 16(1), 68-78.

BACKGROUND: Opioid overdose has a high mortality, but is often reversible with appropriate overdose management and naloxone (opioid antagonist). Training in these skills has been successfully trialled internationally with opioid users themselves. Healthcare professionals working in substance misuse are in a prime position to deliver overdose prevention training to drug users and may themselves witness opioid overdoses. The best method of training dissemination has not been identified. The study assessed post-training change in clinician knowledge for managing an opioid overdose and administering naloxone, evaluated the ‘cascade method’ for disseminating training, and identified barriers to implementation.
METHODS: A repeated-measures design evaluated knowledge pre-and-post training. A sub-set of clinicians were interviewed to identify barriers to implementation. Clinicians from addiction services across England received training. Participants self-completed a structured questionnaire recording overdose knowledge, confidence and barriers to implementation.
RESULTS: One hundred clinicians were trained initially, who trained a further 119 clinicians (n=219) and thereafter trained 239 drug users. The mean composite score for opioid overdose risk signs and actions to be taken was 18.3/26 (+/-3.8) which increased to 21.2/26 (+/-4.1) after training, demonstrating a significant improvement in knowledge (Z=9.2, p<0.001). The proportion of clinicians willing to use naloxone in an opioid overdose rose from 77% to 99% after training. Barriers to implementing training were clinician time and confidence, service resources, client willingness and naloxone formulation.
CONCLUSIONS: Training clinicians how to manage an opioid overdose and administer naloxone was effective. However the ‘cascade method’ was only modestly successful for disseminating training to a large clinician workforce, with a range of clinician and service perceived obstacles. Drug policy changes and improvements to educational programmes for drug services would be important to ensure successful implementation of overdose training internationally.

McAuley, A George, L, Woods, M & Louttit, D (2010), ‘Responsible management and use of a personal take-home naloxone supply: A pilot project’, Drugs: Education, Prevention, and Policy Jul 2010, Vol. 17, No. 4: 388–399.

Responsible management and use of a personal take-home naloxone supply: A pilot project
The results of this project suggest that Scottish drug users can be trained to identify and respond to an opiate overdose utilizing basic life support and naloxone administration skills similar to their counterparts from other parts of the world. Moreover these results suggest that a majority of opiate users can responsibly manage their own personal take-home naloxone supply when trained appropriately.

N-ALIVE team. (2011). Prison-based Naloxone-on-release pilot randomised controlled prevention trial Summary V1.4, 1.2.11. London.

National Treatment Agency for Substance Misuse (2011) The NTA overdose and naloxone training programme for families and carers. London, http://findings.org.uk/count/downloads/download.php?file=NTA_21.txt

Naloxone empowers carers to save lives of overdosing heroin users
Up to 18 lives were known (and more perhaps unrecorded) to have been saved after the National Treatment Agency in England piloted training for the carers of opiate users on how to administer the overdose-reversing drug naloxone. But how does catering for relapse in this way square with the optimism of the recovery movement?

Open Society Foundations (2011) Stopping overdose: peer-based distribution of naloxone. Open Society Foundations Public Health Program. New York, http://www.soros.org/initiatives/health/focus/ihrd/articles_publications/publications/naloxone-20110324.

Overdose is a major and often overlooked cause of death among people who inject heroin or other opioids. Yet there is a safe and effective treatment: the medication naloxone.
This public health fact sheet describes how naloxone is successfully being used to reverse overdose around the world with no side effects beyond opiate withdrawal. It provides real-life examples of programs that have trained drug users, their families and friends to efficiently identify the signs of overdose, administer naloxone, and often, save lives. And, it explains in-depth why naloxone is an invaluable tool for empowering communities to protect their health.

National Treatment Agency for Substance Misuse (2011). The NTA overdose and naloxone training programme for families and carers. National Treatment Agency for Substance Misuse, London, media release: http://www.nta.nhs.uk/news-2011-naloxone-report.aspxand report: http://www.nta.nhs.uk/uploads/naloxonereport2011.pdf.

Does the UK Government really state that naloxone drug kits save lives?
Yes it does! An August 2011 media release from the UK National Treatment Agency reads as follows:
The deaths of at least 20 addicts were prevented during the course of a ground-breaking new trial in which their friends and family were given the heroin “antidote” naloxone and training in life-saving techniques to cope with overdose situations.
At 16 pilot sites around England, 495 carers were trained to respond to an overdose using basic life support techniques. Those at 15 sites were also trained to administer naloxone which reverses the effects of heroin and other opioids for long enough for medical help to arrive.
In a report issued today, the National Treatment Agency for Substance Misuse (NTA) said that during the trial (July 2009 to February 2010) and to date there have been 18 overdoses where carers used naloxone and two where they applied basic life support. All the drug users survived the overdose.
NTA chief executive Paul Hayes said: “Overdoses often occur when friends or family are near at hand and if they can be trained in how to manage such an emergency and keep the victim alive while waiting for the ambulance, potentially hundreds of lives could be saved in the UK every year.
“This project feeds into a key area of our work on preventing drug related deaths. We are also currently supporting local areas to improve the way they review and record such deaths to provide a more robust evidence base to help shape local policies on this important harm reduction and recovery issue.”

Sherman, S. G., Gann, D. S., Tobin, K. E., Latkin, C. A., Welsh, C., & Bielenson, P. (2009). “The life they save may be mine”: Diffusion of overdose prevention information from a city sponsored programme. International Journal of Drug Policy, 20, 137-142.

Tobin, K. E., Sherman, S. G., Beilenson, P., Welsh, C., & Latkin, C. A. (2009). Evaluation of the Staying Alive programme: Training injection drug users to properly administer Naloxone and save lives. International Journal of Drug Policy, 20, 131-136.

Wampler DA, Molina DK, McManus J, Laws P, Manifold CA. (2011). No deaths associated with patient refusal of transport after naloxone-reversed opioid overdose. Prehosp Emerg Care. Jul-Sep;15(3):320-4.

INTRODUCTION: Naloxone is widely used in the treatment and reversal of opioid overdose. Most emergency medical services (EMS) systems administer naloxone by standing order, and titrate only to reverse respiratory depression without fully reversing sedation. Some EMS systems routinely administer sufficient naloxone to fully reverse the effects of opioid overdose. Frequently patients refuse further medical evaluation or intervention, including transport.
OBJECTIVES: The purpose of this study was to evaluate the safety of this practice and determine whether increased mortality is associated with full reversal of opioids. As a component of a comprehensive quality assurance initiative, we assessed mortality during the 48 hours after patients received naloxone to reverse opioid overdose followed by patient-initiated refusal of transportation.
METHODS: The setting was a large urban fire-based EMS system. Investigators provided the Bexar County Medical Examiner’s Office (MEO) with a list of patients who were treated by the San Antonio Fire Department with naloxone, and not transported. Inclusion criteria were administration of naloxone and patient-initiated refusal. Patient dispositions also included aid only, referral to the MEO, or referral to law enforcement. The list was then compared with the MEO database. A chart review was completed on all patients treated and subsequently presented to the MEO within two days. A secondary time period of 30 days was also assessed.
RESULTS: The list identified 592 patients treated with naloxone and not transported to the emergency department. Five-hundred fifty-two patients received naloxone and refused transport or were not transported. The remaining 40 patients all presented to EMS in cardiac arrest, naloxone was administered during the course of resuscitation, and subsequent efforts were terminated in the field. None of the patients receiving naloxone with a subsequent patient-initiated refusal were examined at the MEO within the two-day end point. The 30-day assessment revealed that nine individuals were treated with naloxone and subsequently died, but the shortest time interval between date of service and date of death was four days.
CONCLUSION: The primary outcome was that no patients who were treated with naloxone for opioid overdose and then refused care were examined by the MEO within a 48-hour time frame.

Wermeling, D. P. (2010). Opioid harm reduction strategies: Focus on expanded access to intranasal Naloxone. Pharmacotherapy, 30(7), 627-631.